| 中文名稱 | 貓不明病因的遺傳性的高草酸鹽尿症（L-GLYCERIC ACIDURIA） |
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| 英文名稱 | Primary inherited hyperoxaluria (l-glyceric aciduria) in cats |
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| 建立日期 | 2007/11/01 |
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| 更新日期 | 2007/11/01 |
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| 中文描述 | 5~9個月大的貓,在一密閉的族群中,產生急性腎衰竭及神經症狀. BUN和creatinine的數值皆上升. 腎小管有草酸鹽的沉積;在脊髓腹角的軸突和背側神經節,有神經絲(neurofilaments). 有左旋甘油的酸尿，以及間歇性的高草酸鹽尿。肝組織的分析顯示，D-glycerate dehydrogenase缺乏：此疾病與人類的” II型原發性高草酸鹽尿症”相似，且可能為一種遺傳性疾病。 |
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| 英文描述 | Cats in a closed colony developed acute renal failure and neurological signs at 5-9 months of age. BUN and creatinine were elevated. There was deposition of oxalate crystals in the tubules of the kidney and accumulations of neurofilaments in the proximal axons of the ventral horn cells and dorsal root ganglion cells of the spinal cord. There was L-glyceric aciduria and intermittent hyperoxaluria. Analysis of liver tissue revealed deficiency of D-glycerate dehydrogenase; this disease is analagous to the human disorder 'primary hyperoxaluria type 2' and is probably inherited as a recessive. |
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